關於張家銘醫師

雖然幫人治病是我的職業,不過我卻很不願看到有人生病,因為人生的目的是 : 有個健康的身心,體驗這世界,從中學習,增加自己經驗,並積極發展各項能力,而不是將時間精力花在病痛上。

所以預防及早期治療疾病成為我最關心的事。基因體是個人身體運作獨有的說明書;要預防及早期治療疾病,先了解這本個人說明書是重要關鍵,我現在做的,就是幫大家解讀自己的說明書。

我現在在台北榮總遺傳優生科(婦女醫學部)擔任主治醫師,具醫學博士及部定助理教授資格,為國健署認證之遺傳檢驗機構醫師/主持人,同時為遺傳諮詢中心醫師。

專長是基因/基因體檢測及基因體醫學,熟悉生物資訊、資料科學及基因體數據運算分析及程式設計,及人工智慧,已有多年跨科別、整合分析不同疾病之基因體醫學資料之臨床分析、遺傳諮詢及解說經驗。

基因體醫學強調利用基因體資訊掌握個人不同的健康特性,並據此選擇適合的醫療方式。

為了推廣基因體醫學,筆者成立基因體檢測門診,讓大家有一個明確易找的基因體檢測入口。

研究論文

  1. Chang, C.C.; Su, K.M.; Lu, K.H.; Lin, C.K.; Wang, P.H.; Li, H.Y.; Wang, M.L.; Lin, C.K.; Yu, M.H.; Chang, C.M. Key immunological functions involved in the progression of epithelial ovarian serous carcinoma discovered by the gene ontology-based immunofunctionome analysis. International journal of molecular sciences 2018, 24;19(11).
  2. Chang, C. M.; Wang, M. L.; Lu, K. H.; Yang, Y. P.; Juang, C. M.; Wang, P. H.; Hsu, R. J.; Yu, M. H.; Chang, C. C., Integrating the dysregulated inflammasome-based molecular functionome in the malignant transformation of endometriosis-associated ovarian carcinoma. Oncotarget 2018, 9 (3), 3704-3726.
  3. Chang, C. M.; Yang, Y. P.; Chuang, J. H.; Chuang, C. M.; Lin, T. W.; Wang, P. H.; Yu, M. H.; Chang, C. C., Discovering the Deregulated Molecular Functions Involved in Malignant Transformation of Endometriosis to Endometriosis-Associated Ovarian Carcinoma Using a Data-Driven, Function-Based Analysis. International journal of molecular sciences 2017, 18 (11).
  4. Chang, C. M.; Wang, P. H.; Horng, H. C., Gene set-based analysis of mucinous ovarian carcinoma. Taiwanese journal of obstetrics & gynecology 2017, 56 (2), 210-216.
  5. Chang, C. M.; Lan, K. L.; Huang, W. S.; Lee, Y. J.; Lee, T. W.; Chang, C. H.; Chuang, C. M., 188Re-Liposome Can Induce Mitochondrial Autophagy and Reverse Drug Resistance for Ovarian Cancer: From Bench Evidence to Preliminary Clinical Proof-of-Concept. International journal of molecular sciences 2017, 18 (5).
  6. Chang, C. M.; Chuang, C. M.; Wang, M. L.; Yang, Y. P.; Chuang, J. H.; Yang, M. J.; Yen, M. S.; Chiou, S. H.; Chang, C. C., Gene Set-Based Integrative Analysis Revealing Two Distinct Functional Regulation Patterns in Four Common Subtypes of Epithelial Ovarian Cancer. International journal of molecular sciences 2016, 17 (8).
  7. Chang, C. M.; Chuang, C. M.; Wang, M. L.; Yang, Y. P.; Chuang, J. H.; Yang, M. J.; Yen, M. S.; Chiou, S. H.; Chang, C. C., Gene Set-Based Integrative Analysis Revealing Two Distinct Functional Regulation Patterns in Four Common Subtypes of Epithelial Ovarian Cancer. International journal of molecular sciences 2016, 17 (8).
  8. Chang, C. M.; Chuang, C. M.; Wang, M. L.; Yang, M. J.; Chang, C. C.; Yen, M. S.; Chiou, S. H., Gene Set-Based Functionome Analysis of Pathogenesis in Epithelial Ovarian Serous Carcinoma and the Molecular Features in Different FIGO Stages. International journal of molecular sciences 2016, 17 (6).
  9. Chang, C. M.; Chiou, S. H.; Yang, M. J.; Yen, M. S.; Wang, P. H., Gene set-based integrative analysis of ovarian clear cell carcinoma. Taiwanese journal of obstetrics & gynecology 2016, 55 (4), 552-7.

研究計畫

  1. (108) Predicting complex diseases by a polygenic AI-based model trained with public domain big data (中央研究院生物醫學科學研究所CRC研究計畫: 以公開資料庫大數據訓練多基因人工智慧模式辨認及預測複雜疾病)